Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation

Figure 6

Rates of oxidative metabolism and cardiac function. (a) The rate of palmitate oxidation in isolated working hearts from TMCM, PPARα ^−/−, TMPD, and TMPDPA mice was measured using ²H₂O-labeled palmitate. (b) The rate of glucose oxidation in isolated working hearts from TMCM, PPARα ^−/−, TMPD, and TMPDPA mice was measured using ¹⁴C-labeled glucose. ^∗𝑃<0.05 versus TMCM; ^∗∗𝑃<0.01 versus TMCM.

(a)

(b)