Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation

Table 1

Hemodynamic measurement of isolated working heart.

Parameters	TMCM	Pa	TMPD	TMPDPA
HR	431 ± 20	435 ± 22	410 ± 23	406 ± 16
LVPsys (mmHg)	110.8 ± 3.9	110.5 ± 2.3	94.7 ± 5.6*	105.0 ± 1.7
LVEDP (mmHg)	7.8 ± 1.8	7.8 ± 1.6	9.8 ± 2	12.5 ± 2.8
LVPdia (mmHg)	2.4 ± 1.3	3.7 ± 1.2	5.7 ± 1.8	7.3 ± 3.4
LVPamp (mmHg)	108.4 ± 3.8	106.8 ± 2.6	84.0 ± 5.7**	91.7 ± 5.3*
dLVP d𝑡max (mmHg/s)	6691 ± 518	5999.7 ± 361	5154 ± 332*	5500.9 ± 683.7
−dLVP d𝑡min (mmHg/s)	−5666 ± 428	−4741 ± 330.6	−4635.8 ± 338	−4836.2 ± 614.9

Heart rate: HR; left ventricular systolic pressure: LVPsys; left ventricular end-diastolic pressure: LVEDP; left ventricular diastolic pressure: LVPdia; left ventricular developed pressure: LVPamp; left ventricular developed pressure; first derivative (dLVPd𝑡_max and dLVPd𝑡_min), *𝑃<0.05 versus TMCM, 𝑛=5-8.