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PPAR Research
Volume 2011, Article ID 436358, 10 pages
Research Article

Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats

1Department of Cancer Research and Molecular Medicine, Faculty of Medicine, MTFS, Norwegian University of Science and Technology, NTNU, Olav Kyrres gate 9, 7489 Trondheim, Norway
2Departments of Orthopedics and Internal Medicine, Erasmus University, 3000 DR, Rotterdam, The Netherlands
3Department of Gastroenterology and Hepatology, St. Olav's University Hospital, 7006 Trondheim, Norway
4Department of Medicine, University of Bergen, 5020 Bergen, Norway
5Department of Heart Diseases, Haukeland University Hospital, 5021 Bergen, Norway
6Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, 0317 Oslo, Norway
7Department of Endocrinology, St. Olav's University Hospital, 7030 Trondheim, Norway

Received 28 July 2011; Accepted 6 September 2011

Academic Editor: Beata Lecka-Czernik

Copyright © 2011 Astrid Kamilla Stunes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.