PPAR Research

Research Article

Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats

Table 1

Body weight, fat and lean mass, femoral and whole body bone mineral content (BMC), and bone mineral density (BMD) in rats at baseline and after four months of treatment with TTA (Study I).
Months CTR (controls given vehicle) ( š‘ = 1 2 ) TTA (given TTA) ( š‘ = 1 2 )
Body weight (g) 0 2 1 5 Ā± 1 4 . 0 2 2 0 Ā± 7 . 4 3
4 2 3 5 Ā± 1 5 . 9 2 4 2 Ā± 1 0 . 8
Fat mass (g) 0 4 3 . 6 Ā± 1 0 . 9 4 8 . 8 Ā± 7 . 9 8
4 4 6 . 8 Ā± 1 3 . 7 4 8 . 2 Ā± 1 4 . 5
Lean mass (g) 0 1 6 5 Ā± 8 . 4 4 1 6 0 Ā± 8 . 4 4
4 1 8 3 Ā± 7 . 7 3 1 8 6 Ā± 9 . 3 6
Whole body BMC (g) 0 6 . 3 8 Ā± 0 . 3 5 6 . 3 9 Ā± 0 . 3 5
4 7 . 2 4 Ā± 0 . 3 6 7 . 3 1 Ā± 0 . 3 7
Femoral BMC (g) 0 0 . 3 2 Ā± 0 . 0 2 9 0 . 3 3 Ā± 0 . 0 1 4
4 0 . 7 2 Ā± 0 . 0 3 6 0 . 7 3 Ā± 0 . 0 3 7
Whole body BMD (g/cm2) 0 0 . 1 4 2 Ā± 0 . 0 0 7 0 . 1 4 4 Ā± 0 . 0 1 0
4 0 . 1 5 9 Ā± 0 . 0 0 8 0 . 1 5 4 Ā± 0 . 0 0 5
Femoral BMD (g/cm2) 0 0 . 2 3 3 + 0 . 0 1 0 0 . 2 3 5 Ā± 0 . 0 0 6
4 0 . 2 4 5 Ā± 0 . 0 0 9 0 . 2 5 6 Ā± 0 . 0 1 1 a
Data are presented as mean Ā± SD, a š‘ƒ < 0 . 0 5 significantly different compared to control.