Research Article

Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats

Table 4

Body weight, fat and lean mass, femoral and whole body bone mineral content (BMC), and bone mineral density (BMD) in mean values ± SEM in sham controls, ovariectomized controls, and ovariectomized rats fed TTA, at baseline, and after two and four months (Study II).

Months SHAM
(sham-operated controls)
( 𝑁 = 1 0 )
OVX
(ovariectomized controls)
( 𝑁 = 1 0 )
TTA OVX
(ovariectomized, given TTA)
( 𝑁 = 1 0 )

Body weight (g) 0 2 6 4 . 1 ± 5 . 6 2 7 7 . 3 ± 4 . 5 2 7 3 . 7 ± 1 1 . 7
2 2 8 0 . 6 ± 6 . 0 3 3 9 . 2 ± 5 . 7 aaa 3 3 8 . 2 ± 1 6 . 2 aaa
4 2 8 8 . 9 ± 6 . 0 3 5 1 . 8 ± 7 . 1 aaa 3 5 2 . 5 ± 1 7 . 8 aaa

Fat mass (g) 0 2 1 . 6 ± 2 . 6 1 8 . 2 ± 1 . 9 2 0 . 1 ± 4 . 2
2 2 7 . 3 ± 1 . 6 3 8 . 8 ± 3 . 0 aaa 3 7 . 2 ± 7 . 2 aaa
4 2 8 . 3 ± 2 . 1 5 5 . 8 ± 4 . 9 aaa 5 1 . 1 ± 8 . 4 aaa

Lean mass (g) 0 2 3 3 . 9 ± 3 . 5 2 5 0 . 7 ± 3 . 8 2 4 8 . 4 ± 1 4 . 4
2 2 4 4 . 0 ± 5 . 5 2 9 0 . 1 ± 5 . 6 aaa 2 9 1 . 0 ± 2 0 . 0 aaa
4 2 5 1 . 1 ± 4 . 9 2 8 5 . 7 ± 5 . 9 aaa 2 9 1 . 0 ± 1 4 . 9 aaa

Whole body BMC (g) 0 8 . 5 1 ± 0 . 1 6 8 . 4 1 ± 0 . 1 6 8 . 6 9 ± 0 . 5 2
2 9 . 3 4 ± 0 . 1 6 9 . 8 1 ± 0 . 2 0 1 0 . 0 7 ± 0 . 4 8
4 9 . 5 6 ± 0 . 1 8 1 0 . 3 3 ± 0 . 1 9 1 0 . 3 2 ± 0 . 4 8

Femur BMC (g) 0 0 . 4 1 8 ± 0 . 0 0 5 0 . 4 0 9 ± 0 . 0 1 0 0 . 4 3 0 ± 0 . 0 3 0
2 0 . 4 6 3 ± 0 . 0 1 1 0 . 4 4 4 ± 0 . 0 0 8 0 . 4 6 4 ± 0 . 0 2 5
4 0 . 4 8 9 ± 0 . 0 1 1 0 . 4 5 6 ± 0 . 0 0 7 a 0 . 4 7 1 ± 0 . 0 2 5

Whole body BMD (g/cm2) 0 0 . 1 7 3 ± 0 . 0 0 1 0 . 1 7 1 ± 0 . 0 0 1 0 . 1 7 5 ± 0 . 0 0 5
2 0 . 1 8 5 ± 0 . 0 0 2 0 . 1 7 9 ± 0 . 0 0 2 0 . 1 8 1 ± 0 . 0 0 5
4 0 . 1 8 4 ± 0 . 0 0 1 0 . 1 7 8 ± 0 . 0 0 2 aaa 0 . 1 7 8 ± 0 . 0 0 4 a

Femur BMD (g/cm2) 0 0 . 3 0 5 ± 0 . 0 0 6 0 . 2 9 2 ± 0 . 0 0 4 0 . 3 0 2 ± 0 . 0 1 7
2 0 . 3 1 2 ± 0 . 0 0 4 0 . 2 9 3 ± 0 . 0 0 2 0 . 2 9 9 ± 0 . 0 1 0
4 0 . 3 1 9 ± 0 . 0 0 4 0 . 2 9 4 ± 0 . 0 0 3 aaa 0 . 2 9 5 ± 0 . 0 0 9 aa

a,  aa,  aaa 𝑃 < 0 . 0 5 , 𝑃 < 0 . 0 1 , 𝑃 < 0 . 0 0 1 when compared to CTR SHAM group.