A Comparative Study of Mouse Hepatic and Intestinal Gene
Expression Profiles under PPARα Knockout by
Gene Set Enrichment Analysis
Comparison of PPARα-independent or WY14643-dependent regulated pathways between in small intestine and liver of mice. Venn diagram showing the overlapping significantly identified pathways by the comparison of PPARα-independent or WY14643-dependent regulated pathways between in small intestine and liver of mice. The studies of Intestine-WT (CT/WY) and Liver-WT (CT/WY) are for identifying WY14643-dependent pathways; the studies of Intestine-KO (CT/WY) and Liver-KO (CT/WY) are for identifying PPARα-independent pathways, respectively, in mice small intestine and liver. Pathways of value less than 0.01 were considered to be significantly regulated. Red color is for upregulated pathways and green color is for downregulated pathways. In (a), there were 30 upregulated and 34 downregulated WY14643-dependent pathways in common; in (b), there were only 4 upregulated and 8 downregulated PPARα-independent pathways in common in both tissues of mice.