Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells

<table>Atherogenic <i>ω</i>-6 lipids modulate PPAR-Egr-1 crosstalk.  A schematic representation of a possible mechanism by which <i>ω</i>-6 lipids and their oxidized forms regulate PPAR-Egr-1 crosstalk in a time-mediated fashion and thereby altering smooth muscle cell function. <i>ω</i>-6 lipids seemed to have a time-dependent modulation of PPAR isotypes, PPAR<i>α</i> at acute phase and PPAR<i>γ</i> at subacute phase. This modulation of PPAR isotype altered the ability of these lipids to exert an antiatherogenic effects via PPARs or proatherogenic effects via Egr-1.</table>

PPAR Research

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Scheme 1

Scheme 1: Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells 