Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor 𝜸 Agonist In Vivo

Figure 1

Involvement of PPARγ on carrageenan-induced paw edema in mice. (a) Dose-dependence and time course of PPARγ agonist, pioglitazone on carrageenan-induced paw edema in mice. Pioglitazone was orally administrated 3 h before carrageenan injection at doses of 1, 3, and 10 mg/kg. The control group received 0.5% carboxymethylcellulose. (b) Effect of PPARγ antagonist, GW9662 on pioglitazone induced anti-inflammatory effect. Pioglitazone was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. GW9662 was injected 15 min before carrageenan injection at doses of 1 and 3 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (𝑛=7). *,**: Significantly different from the control group at 𝑃<0.05 and 𝑃<0.01, respectively, (Dunnett’s test). ^†,^††: Significantly different from the vehicle group at 𝑃<0.05 and 𝑃<0.01, respectively, (Dunnett’s test).

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