Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity
Correlation between liver phospholipid content of LCPUFA n-3 and F2-isoprostane levels in serum as index of oxidative stress (a) and contents of liver triacylglycerols (b), palmitic acid (c), and protein carbonyls (d) in control subjects and obese patients with steatosis. LCPUFA n-3 content corresponds to eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA), expressed as g/100 g fatty acid methyl esters (FAME). Correlation in (a) was carried out by Spearman rank order correlation coefficient (unpublished data). Data (means ± SEM; 10 controls and 8 obese patients with steatosis) presented in (b), (c), and (d) were adapted from Araya et al., 2004 .