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PPAR Research
Volume 2012, Article ID 164140, 9 pages
http://dx.doi.org/10.1155/2012/164140
Review Article

Coordinated Regulation of PPAR 𝛾 Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

1Université Lille Nord de France, 59000 Lille, France
2Inserm, U1011, 59000 Lille, France
3UDSL, 59000 Lille, France
4Institut Pasteur de Lille, 59019 Lille, France

Received 14 March 2012; Accepted 10 July 2012

Academic Editor: Andrea Galli

Copyright © 2012 Jérôme Eeckhoute et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes. Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells. Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure. Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling. In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.