Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver

Table 1

Body, liver weights and TG levels after treatment with plasticizers for 2 weeks.

		B.W.	Liver weight	Liver weight/ B.W. (%)	Plasma TG	Liver TG
mPParα	Control	23.9±0.91	0.88±0.11	3.68±0.38	79.4±16.3	14.8±1.53
	DBP 2.5	25.9±2.05	1.08±0.13	4.14±0.17	89.9±24.8	12.5±2.76
	DBP 5.0	26.7±2.01	1.20±0.10^∗	4.49±0.40	113.9±40.4	11.4±1.68
	DEHP 2.5	22.1±1.82	1.13±0.11^∗	5.09±0.24^∗	82.6±13.8	11.6±1.56
	DEHP 5.0	22.9±0.92	1.26±0.06^∗	5.54±0.33^∗	84.0±24.5	6.8±0.90^∗
	DEHA 2.5	25.9±0.85	1.20±0.07^∗	4.63±0.22^∗	136.9±15.9	11.4±0.90
	DEHA 5.0	24.2±1.81	1.28±0.18^∗	5.27±0.35^∗	119.5±36.3	7.5±1.76^∗
hPParα	Control	22.7±2.20	1.04±0.06	4.59±0.25	97.0±23.6	24.4±5.51^#
	DBP 2.5	25.0±2.32	1.07±0.08	4.29±0.18	127.0±35.0	22.6±4.66
	DBP 5.0	23.1±4.51	1.05±0.28	4.76±0.29	95.1±26.0	31.9±19.31
	DEHP 2.5	23.8±2.58	1.12±0.17	4.69±0.25	111.5±28.0	20.6±4.66
	DEHP 5.0	21.6±2.58	1.03±0.17	4.52±0.37	67.8±35.0	30.9±4.24^∗
	DEHA 2.5	24.9±1.03	1.12±0.08	4.48±0.14	142.3±59.9	23.1±1.98
	DEHA 5.0	24.7±2.94	1.23±0.17	4.98±0.25	176.0±41.0^∗	28.4±2.73

B.W: body weight.
Each value represents mean ± S.D. *Significantly different from respective controls (𝑃<0.05). ^#Significantly different from mPPARα controls (𝑃<0.05).