Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury
Figure 1
Effect of 5 mg/kg rosiglitazone (RGZ) on parameters of renal function in Sprague-Dawley rats in renal I/R injury. After either a sham operation or a bilateral clamping of the renal arteries for 60 min, rosiglitazone was applied i.p. or not, and parameters of renal function were determined 24 h afterwards. Parameters were additionally determined in untreated control rats. n as indicated. #Statistically significant difference as indicated. (a) Renal clearance of inulin was determined as a measure of GFR as described in Section 2 (GFR = , where IU is inulin concentration in urine, IP is inulin concentration in plasma, VU is urine volume, t is time of measurement, and GFR is glomerular filtration rate). (b) Renal clearance of PAH was determined as described in Section 2 (PAH clearance = , where PAHU is PAH concentration in urine, PAHP is PAH concentration in plasma). (c) Renal net secretion of PAH (PNS) was determined as described in Section 2 .
