PPAR Research / 2012 / Article / Fig 1

Research Article

Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury

Figure 1

Effect of 5 mg/kg rosiglitazone (RGZ) on parameters of renal function in Sprague-Dawley rats in renal I/R injury. After either a sham operation or a bilateral clamping of the renal arteries for 60 min, rosiglitazone was applied i.p. or not, and parameters of renal function were determined 24 h afterwards. Parameters were additionally determined in untreated control rats. n as indicated. #Statistically significant difference as indicated. (a) Renal clearance of inulin was determined as a measure of GFR as described in Section 2 (GFR = , where IU is inulin concentration in urine, IP is inulin concentration in plasma, VU is urine volume, t is time of measurement, and GFR is glomerular filtration rate). (b) Renal clearance of PAH was determined as described in Section 2 (PAH clearance = , where PAHU is PAH concentration in urine, PAHP is PAH concentration in plasma). (c) Renal net secretion of PAH (PNS) was determined as described in Section 2 .
219319.fig.001a
(a)
219319.fig.001b
(b)
219319.fig.001c
(c)

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.