Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury

Figure 7

Schematic figure of factors contributing to renal dysfunction in ischemia/reperfusion injury. The downregulation of eNOS causes endothelial dysfunction and vasoconstriction. The upregulation of iNOS in acute kidney injury is associated with an increase in cell apoptosis and inflammatory cell damage. Moreover, elevated levels of iNOS directly suppress the expression of eNOS. The application of rosiglitazone in ischemic acute kidney injury and reperfusion may help to correct the imbalance of eNOS/iNOS expression.