AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

Figure 1

Caco-2 cell proliferation. (a) Growth of Caco-2 cells treated with clofibrate at the indicated concentrations (from 1 to 50 μM) and at different times; (b) growth of Caco-2 cells treated with AS601245 at the indicated concentrations (from 0,1 to 10 μM) and at different times; (c) growth of Caco-2 cells treated with 5 μM clofibrate, 0,1 μM AS601245, and the association of these two compounds (Clofi + AS601245). Cell proliferation was detected by measuring the luminescence released by the metabolically active cells. The values expressed in RLU (relative light units) are the means ± SD of three separate experiments. Variance analysis: *𝑃<0.05, **𝑃<0.01 versus control.

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