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PPAR Research
Volume 2012, Article ID 269751, 16 pages
http://dx.doi.org/10.1155/2012/269751
Research Article

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

1MerckSerono Ivrea, Istituto di Ricerche Biomediche “A. Marxer”, RBM S.p.A., 10010 Colleretto Giacosa, Italy
2Department of Medicine and Experimental Oncology, Section of General Pathology, University of Turin, 10125 Turin, Italy
3Department of Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology and Pharmacognosy, University of Turin,10125 Turin, Italy
4Department of Anatomy, Pharmacology, and Forensic Medicine, Section of Pharmacology and Experimental Therapy, University of Turin, 10125 Turin, Italy

Received 2 August 2011; Revised 29 October 2011; Accepted 1 November 2011

Academic Editor: J. Reddy

Copyright © 2012 Angelo Cerbone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table A shows the complete affimetrix analysis of genes modulated by 5 µCM Clofibrate, 0.1 µM AS601245 and by the combined treatment with Clofibrate and AS601245 and listed on the basis of the p-value. Table B indicates gene relative expression detected by affymetrix and quantitative real-time reverse transcription PCR in Caco-2 cells treated with 5 µM Clofibrate, 0.1 µM AS601245 and combined treatment. Table C lists the genes affected by Clofibrate, by AS601245, and by the combined treatment, arranged with respect to the relative biological functions and listed on the basis of the p-value.

  1. Supplementary Material 1
  2. Supplementary Material 2
  3. Supplementary Material 3