PPAR𝜶-Independent Arterial Smooth Muscle Relaxant Effects of PPAR𝜶 Agonists

Figure 5

Exploration of the mechanism of PPARα agonist-mediated dilation in MCAs. (a) 10⁻⁵ M L-name and indomethacin pretreatment did not alter dilation to GW7647 in PE-preconstricted MCAs (𝑛=4). Likewise, in MCAs pretreated with high K⁺, dilation to GW7647 was again unaltered (𝑛=4). (b) In MCAs, pretreatment with phorbol 12,13-dibutyrate, as well as with 10⁻⁵ M ODQ (𝑛=5) impaired the dilatory response of GW7647 thereby implicating a role for PKC and sGC in the response (𝑛=3). Data are means ± SEM. *Indicates P ≤ 0.05.

(a)

(b)