302495.fig.005a
(a)
302495.fig.005b
(b)
Figure 5: Exploration of the mechanism of PPARα agonist-mediated dilation in MCAs. (a) 10−5 M L-name and indomethacin pretreatment did not alter dilation to GW7647 in PE-preconstricted MCAs ( 𝑛 = 4 ). Likewise, in MCAs pretreated with high K+, dilation to GW7647 was again unaltered ( 𝑛 = 4 ). (b) In MCAs, pretreatment with phorbol 12,13-dibutyrate, as well as with 10−5 M ODQ ( 𝑛 = 5 ) impaired the dilatory response of GW7647 thereby implicating a role for PKC and sGC in the response ( 𝑛 = 3 ). Data are means ± SEM. *Indicates P ≤ 0.05.