The Impact of PPAR𝜸 Genetic Variants on IBD Susceptibility and IBD Disease Course

Table 2

Genetic variants detected in NR1C3.

SNP no.	Position in DNA^( a)	Exon/ intron no.	Exon position	Intron/ exon	Base exchange	Position in RNA^(b)	AA exchange^(c)	SNP database
1	12332979	1		Intron	G>T		NA	Not found
2	12333068	1		Exon	insC	68	frame shift	Not found
3	12333070	1		5-prime	C>T	70	5-prime	Not found
4	12333125	1	12333001–12333173	Exon	C>G	125	12 P [Pro]>A [Ala]	rs1801282
5	12333199	1		Intron	T>G		NA	Not found
6	12333213	1		Intron	G>A		NA	Not found
7	12361272	2	12361203–12361430	Exon	C>T	243	51 S [Ser]>F [Phe]	Not found
8	12361422	2		Exon	A>G	393	101 E [Glu]>G [Gly]	Not found
9	12363017	3	12362821–12362990	Intron	A>G		NA	Not found
10	12374014	4		Intron	G>T		NA	Not found
11	12374024	4		Intron	A>T		NA	Not found
12	12374091	4		Intron	C>A		NA	rs4135333
13	12374110	4		Intron	C>T		NA	Not found
14	12374272	4	12374113–12374251	Intron	A>T		NA	rs4135334
15	12374352	4		Intron	C>T		NA	Not found
16	12387616	5	12387381–12387580	Intron	G>A		NA	Not found
17	12398613	6	12398203–12398653	Exon	C>T	1321	410 S [Ser]>S [Ser]	Not found
18	12415473	7		Exon	G>A	1438	449 L [Leu]>L [Leu]	Not found
19	12415557	7	12415397–12415855	Exon	C>T	1522	477 H [His]>H [His]	rs3856806
20	12415581	7		Exon	G>A	1546	485 K [Lys]>K [Lys]	Not found
21	12415647	7		Exon	G>A	1611	506 stop>stop	Not found
22	12415669	7		3′ end	C>T		3′ end	Not found

no.: number; AA: amino acid; ^(a)DNA reference sequence NT_02257.18; ^(b)RNA reference sequence NM_015869.4; ^(c)protein reference sequence P37231 (PPARG_HUMAN) SWISSPROT database.