The Impact of PPAR𝜸 Genetic Variants on IBD Susceptibility and IBD Disease Course

Table 4

Number of variant carriers in IBD and in non-IBD controls.

SNP	SNP carriers in IBD		SNP carriers in controls		OR (CI)	𝑃^(a)
	N of subjects	N (%) of variant carriers	N of subjects	N (%) of variant carriers
12332979G>T	283	0 (0)	182	1 (0.5)	NA	0.39
12333068insC	283	1 (0.4)	181	0 (0)	NA	0.61
12333070C>T	283	0 (0)	181	1 (0.6)	NA	0.39
12333125A>G	283	58 (20.5)	182	48 (26.4)	0.72	0.14^(b), (c)
12333125A>G	227	Hom only: 2 (0.9)	136	Hom only: 2 (1.5)	0.60	0.63^(c)
12333199T>G	283	1 (0.4)	181	0 (0)	NA	0.61
12333213G>A	283	0 (0)	182	3 (1.6)	NA	0.06
12361272C>T	281	1 (0.4)	179	0 (0)	NA	0.61
12361422A>G	281	0 (0)	179	1 (0.6)	NA	0.39
12363017A>G	277	1 (0.4)	167	0 (0)	NA	0.62
12374014G>T	280	1 (0.4)	174	0 (0)	NA	0.62
12374024A>T	280	1 (0.4)	174	0 (0)	NA	0.62
12374091C>A	280	1 (0.4)	174	0 (0)	NA	0.62
12374110C>T	280	1 (0.4)	174	0 (0)	NA	0.62
12374272A>T	280	1 (0.4)	174	1 (0.6)	0.62	0.62
12374352C>T	280	0 (0)	174	1 (0.4)	NA	0.38
12387616G>A	282	1 (0.4)	179	0 (0)	NA	0.61
12398613C>T	281	0 (0)	185	1 (0.5)	NA	0.40
12415473G>A	273	0 (0)	175	1 (0.6)	NA	0.39
12415557C>T	273	63 (23.1)	175	42 (24)	0.95	0.82^(b ), (c)
12415557C>T	213	Hom only: 3 (1.4)	137	Hom only: 4 (2.9)	0.48	0.44^(c)
12415581G>A	273	0 (0)	175	1 (0.6)	NA	0.39
12415647G>A	273	2 (0.7)	175	0 (0)	NA	0.37
12415669C>T	273	0 (0)	175	1 (0.6)	NA	0.39

OR: odds ratio; CI: confidence interval; no.: number; N: absolute number; het: heterozygous; hom: homozygous; NA: not applicable; ^(a)𝑃 values calculated with Fisher’s exact test; ^(b)𝑃 value calculated with Chi-Square test; ^(c) 12333125A>G: adjusted for age and sex: 𝑃=0.14 (OR 0.72 C.I. (0.46–1.11)) (het + hom); 𝑃=0.53 (hom. only); 12415557C>T: adjusted for age and sex: 𝑃=0.76 (OR 0.93 C.I. (0.59–1.46)) (het + hom), 𝑃=0.35 (OR 0.7 C.I. (0.33–1.49)) (hom only).