Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

<table>The role of PPAR<i>γ</i> and the UPS in the regulation of p16/CDK4/Cyclin D/Rb axis. Dysfunction of this axis promotes cell proliferation and carcinogenesis. Cyclin D is a transcriptional repression target of PPAR<i>γ</i> and a substrate for ubiquitination leading to degradation by the proteasome.</table>

PPAR Research

fig3

Figure 3

Figure 3: Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer 