Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

Figure 5

A schematic representation of the role of PPARγ and UPS in inflammation. UPS regulates NF-κB (here subunits p65 and p50 are depicted) in multiple points, one of which is degradation of inhibitor IκB. Activated NF-κB cooperates with Notch in the induction of Hes. Hes is a transcriptional repressor of PPARγ and thus inflammation is promoted.