Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling

Figure 1

Effects of rhein on body and fat weight in 𝑑𝑏/𝑑𝑏 mice. (a) Structure of rhein. (b) Body weight. (c) Fat, lean, and fluid weight. (d) Food intake amount. The mice were dosed each day for 2 weeks with either emodin or rhein (100 mg kg⁻¹ day⁻¹) in a water vehicle or vehicle only using an oral gavage. The food intake amount was recorded every 24 hours through the treatment. Values are mean ± SE for 5 mice per group. *𝑃<0.05, versus vehicle control.

(a)

(b)

(c)

(d)