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PPAR Research
Volume 2012, Article ID 456529, 10 pages
Review Article

The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes

Division of Diabetic Complications, Baker IDI Heart and Diabetes Institute, P.O. Box 6492, Melbourne, VIC 8008, Australia

Received 9 September 2011; Revised 21 November 2011; Accepted 21 November 2011

Academic Editor: Brian Finck

Copyright © 2012 M. C. Thomas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed on their cardiovascular effects, both positive and negative, these agents also have significant renoprotective actions in the diabetic kidney. Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.