|
ABC transporter | Ligand | Receptor | Model | Transporter effect | Reference |
|
ABCA1 | PPARα | Fenofibrate | Hypertriglyceridemic patients | Differential HDL synthesis due to ABCA1 variants | [87] |
| | | | | |
| | WY14643 | SV129 mice | ↑ Abca1 mRNA and protein in intestine | [88] |
| | | | ↓ intestinal absorption of cholesterol | |
| | | | | |
| PPAR | Telmisartan | ApoE−/− C57BL mice | ↑ Abca1 mRNA in aorta | [63] |
| | | | ↓ atherosclerotic lesion size and number | |
|
Pgp/MDR1/ABCB1 | PPARα | Ciprofibrate | SV129 mice | ↑ hepatic Mdr1 & Mdr3 mRNA | [73] |
|
MDR2/MDR3/ABCB4 | PPAR | Bezafibrate | CF1 mice | ↑ hepatic Mdr2 mRNA | [78] |
| | | | ↑ bile secretion of phospholipid | |
| | | | | |
| | | Humanized liver-uPA/SCID chimeric mice | ↑ hepatic MDR2/MDR3 mRNA and protein | [71] |
| | | | ↑ hepatic MDR2/MDR3 redistribution into bile canaliculi | |
| | | | | |
| | Ciprofibrate | SV129 mice | ↑ hepatic Mdr2 mRNA and protein | [73] |
| | | | ↑ bile secretion of cholesterol and phospholipids | |
| | | | | |
| | | CF1 mice | ↑ hepatic Mdr2 mRNA | [78] |
| | | | ↑ Mdr2 redistribution into bile canaliculi | |
| | | | ↑ bile secretion of phospholipid | |
| | | | | |
| | Clofibrate | CF1 mice | ↑ hepatic Mdr2 mRNA | [78] |
| | | | ↑ Mdr2 redistribution into bile canaliculi | |
| | | | ↑ bile secretion of phospholipid | |
| | | | | |
| | Fenofibrate | CF1 mice | ↑ hepatic Mdr2 mRNA | [78] |
| | | | | |
| | Gemfibrozil | CF1 mice | ↑ hepatic Mdr2 mRNA | [78] |
|
MRP1/ABCC1 | PPAR | Ciprofibrate | C57BL mice | ↓ hepatic Mrp1 mRNA | [83] |
| | | | | |
| | Clofibrate | C57BL mice | ↓ hepatic Mrp1 mRNA | [83] |
| | | | | |
| | GW7647 | C57BL mice | ↓ Mrp1 mRNA in small intestine | [85] |
| | | | | |
| | WY14643 | C57BL mice | ↓ Mrp1 mRNA in small intestine | [85] |
|
MRP2/ABCC2 | PPAR | Clofibrate | Sprague-Dawley rats | ↓ hepatic Mrp2 protein | [89] |
| | | | | |
| | DEHP | Sprague-Dawley rats | ↓ hepatic Mrp2 protein | [89] |
| | | | | |
| | PFDA | Sprague-Dawley rats | ↓ hepatic Mrp2 protein | [89] |
|
MRP3/ABCC3 | PPAR | Ciprofibrate | C57BL mice | ↑ hepatic Mrp3 mRNA | [83] |
| | | | | |
| | Clofibrate | C57BL mice | ↑ hepatic Mrp3 mRNA | [83] |
| | | | | |
| | | CD1 mice | ↑ hepatic Mrp3 mRNA and protein | [82] |
| | | SV129 mice | | |
| | | | | |
| | DEHP | C57BL mice | ↑ hepatic Mrp3 mRNA | [83] |
| | | | | |
| | PFDA | C57BL mice | ↑ hepatic Mrp3 mRNA | [84] |
| | | | ↑ serum levels of bilirubin and bile acids | |
|
MRP4/ABCC4 | PPAR | Clofibrate | CD1 mice | ↑ hepatic Mrp4 mRNA and protein | [82] |
| | | SV129 mice | | |
| | | | | |
| | PFDA | C57BL mice | ↑ hepatic Mrp3 mRNA | [84] |
| | | | ↑ serum levels of bilirubin and bile acids | |
|
ABCG1 | PPAR | Fenofibrate | Zucker diabetic fatty rats | ↑ Abcg1 mRNA | [90] |
| | | | ↑ HDL particle size | |
| | | | | |
| PPAR | Telmisartan | ApoE−/− C57BL mice | ↑ Abcg1 mRNA in aorta | [63] |
| | | | ↓ atherosclerotic lesion size and number | |
|
BCRP/ABCG2 | PPAR | Clofibrate | CD1 mice | ↑ hepatic Bcrp mRNA and protein | [82] |
| | | | | |
| | | SV129 mice | ↑ hepatic Bcrp mRNA | [82] |
| | | | | |
| | GW7647 | C57BL mice | ↑ Bcrp mRNA in small intestine | [85] |
| | | | | |
| | WY14643 | C57BL mice | ↑ Bcrp mRNA in small intestine | [85] |
|