PPARs Signaling and Cancer in the Gastrointestinal System

Figure 1

Schematic representation of the PPARs signaling operating in cancer. Krueppel-like factor 4 (KLF4); cyclin-dependent kinase (2, 4); cyclin B1, D1; ubiquitin-like, containing PHD and RING finger domains, 1; methyl CpG binding protein 2 (MeCP2); Histone deacetylase 1(HDAC1); histone-lysine N-methyltransferase (EZH2); matrix metallopeptidase 2 (MMP2); plasminogen activator inhibitor 1 (PAI-1) nuclear factor-kappaB (NF𝜅B); nucleophosmin (NPM); insulin receptor substrate 1 (IRS-1); suppressor of cytokine signal (SOCS). For further explanations, please refer to the text.