Table 1
Experimental data for PPARΞ³-modulated genes during oxidative stress.
| Target | Effect | Tissue or cell type | Type of evidence | References |
| Bcl-2 | β expression | Cardiomyocyte and glial cells | In vitro | [47, 49] | Catalase | β expression | Adipocytes, microvascular endothelial cells | In vitro | [45, 46] | CD36 | β expression | Macrophages | In vitro | [53, 54] | COX-2 | ββ expression | Hepatocytes, neurons, pancreatic islets, macrophages, astrocytes | In vitro In vivo | [29, 41, 57β59, 63] | eNOS | β expression | Endothelial cell | In vivo | [33] | GPx3 | β expression | Skeletal muscle cells | In vitro | [52] | HO-1 | ββ expression | Hepatocytes, human vascular cells, retina, hippocampal neurons, | In vitro In vivo | [41, 50, 55, 56] | iNOS | β expression | Neurons, macrophages, pancreatic islets, Schwann cells | In vivo In vitro | [29, 57β59, 62] | MnSOD | β expression β activity | Hippocampal neurons, heart | In vivo | [50, 51] | UCP2 | β expression | Sympathetic premotor neurons, liver | In vivo | [35, 38] |
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β = increasing; β = decreasing; ββ= increasing and decreasing effects described.
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