PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

Table 1

Experimental data for PPARγ-modulated genes during oxidative stress.


Target	Effect	Tissue or cell type	Type of evidence	References

Bcl-2	↑ expression	Cardiomyocyte and glial cells	In vitro	[47, 49]
Catalase	↑ expression	Adipocytes, microvascular endothelial cells	In vitro	[45, 46]
CD36	↑ expression	Macrophages	In vitro	[53, 54]
COX-2	↑↓ expression	Hepatocytes, neurons, pancreatic islets, macrophages, astrocytes	In vitro In vivo	[29, 41, 57–59, 63]
eNOS	↑ expression	Endothelial cell	In vivo	[33]
GPx3	↑ expression	Skeletal muscle cells	In vitro	[52]
HO-1	↑↓ expression	Hepatocytes, human vascular cells, retina, hippocampal neurons,	In vitro In vivo	[41, 50, 55, 56]
iNOS	↓ expression	Neurons, macrophages, pancreatic islets, Schwann cells	In vivo In vitro	[29, 57–59, 62]
MnSOD	↑ expression ↑ activity	Hippocampal neurons, heart	In vivo	[50, 51]
UCP2	↑ expression	Sympathetic premotor neurons, liver	In vivo	[35, 38]

↑ = increasing; ↓ = decreasing; ↑↓= increasing and decreasing effects described.