Table 1: Experimental data for PPARγ-modulated genes during oxidative stress.

Target Effect Tissue or cell type Type of evidence References Bcl-2 ↑ expression Cardiomyocyte and glial cells In vitro [47, 49] Catalase ↑ expression Adipocytes, microvascular endothelial cells In vitro [45, 46] CD36 ↑ expression Macrophages In vitro [53, 54] COX-2 ↑↓ expression Hepatocytes, neurons, pancreatic islets, macrophages, astrocytes In vitro In vivo [29, 41, 57–59, 63] eNOS ↑ expression Endothelial cell In vivo [33] GPx3 ↑ expression Skeletal muscle cells In vitro [52] HO-1 ↑↓ expression Hepatocytes, human vascular cells, retina, hippocampal neurons, In vitro In vivo [41, 50, 55, 56] iNOS ↓ expression Neurons, macrophages, pancreatic islets, Schwann cells In vivo In vitro [29, 57–59, 62] MnSOD ↑ expression ↑ activity Hippocampal neurons, heart In vivo [50, 51] UCP2 ↑ expression Sympathetic premotor neurons, liver In vivo [35, 38]

↑ = increasing; ↓ = decreasing; ↑↓= increasing and decreasing effects described.