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PPAR Research
Volume 2012 (2012), Article ID 687492, 12 pages
http://dx.doi.org/10.1155/2012/687492
Review Article

PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis

Department of Biological, Geological and Environmental Sciences, University of Sannio, via Port'Arsa 11, 82100 Benevento, Italy

Received 27 February 2012; Accepted 21 April 2012

Academic Editor: Bart Staels

Copyright © 2012 Lina Sabatino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. Epigenetics adds a further layer of complexity to gene regulation in several biological processes. In cancer, the relationship with epigenetic modifications has provided important insights into the underlying molecular mechanisms. These studies have highlighted how epigenetic modifications influence PPARG gene expression in colorectal tumorigenesis. In this paper, we take a comprehensive look at the current understanding of the relationship between PPARγ and cancer development. The role that epigenetic mechanisms play is also addressed disclosing novel crosstalks between PPARG signaling and the epigenetic machinery and suggesting how this dysregulation may contribute to colon cancer development.