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PPAR Research
Volume 2012 (2012), Article ID 687570, 6 pages
http://dx.doi.org/10.1155/2012/687570
Review Article

The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis

Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480717, Republic of Korea

Received 29 May 2012; Accepted 16 July 2012

Academic Editor: Valerio Pazienza

Copyright © 2012 Jong-Min Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPAR plays an important role in gastric mucosal injury due to Helicobacter pylori (H. pylori). As H. pylori infection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPAR in H. pylori infection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPAR in H. pylori infection and its related gastric carcinogenesis.