Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease
Table 1
(a) Top 20 downregulated gene ontology biological process gene sets in PIO-treated compared with vehicle-treated kidneys. The name of biological process is listed in order of nominal value. (b) Upregulated gene ontology biological process gene sets in PIO-treated compared with vehicle-treated kidneys. The name of biological process is listed in order of nominal value.
(a)
Name of biological process gene sets
Number of genes in the gene set
Nominal value
Defense response
98
0.000
Regulation of cell proliferation
136
0.000
Cell cycle phase
53
0.000
Positive regulation of cell proliferation
64
0.000
Cell cycle process
61
0.000
Positive regulation of cellular process
258
0.000
Cellular morphogenesis during differentiation
22
0.001
Positive regulation of developmental process
91
0.001
Immune system process
128
0.001
Cellular defense response
19
0.003
Neuron differentiation
35
0.004
Negative regulation of cell proliferation
73
0.004
Neurite development
27
0.005
G Protein signaling coupled to ip3 second messenger phospholipase C activating
