Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Table 3

(a) Top 20 downregulated curated gene sets of canonical pathways in PIO-treated compared with vehicle-treated kidneys. The name of biological process is listed in order of nominal 𝑃 value. (b) Upregulated curated gene sets of canonical pathways in PIO-treated compared with vehicle-treated kidneys. The name of biological process is listed in order of nominal 𝑃 value.

(a)

Name of biological process gene sets	Number of genes in the gene set	Nominal 𝑃 value
HSA04640 hematopoietic cell lineage	32	0.000
HSA04610 complement and coagulation cascades	37	0.000
HSA04510 focal adhesion	110	0.001
Breast cancer estrogen signaling	60	0.001
HSA04060 cytokine cytokine receptor interaction	99	0.002
HSA04912 GNRH Signaling Pathway	64	0.002
HSA04110 cell cycle	44	0.003
HSA01430 cell communication	39	0.004
IL1R pathway	15	0.007
Eicosanoid synthesis	15	0.009
HSA04512 ECM receptor interaction	41	0.009
Cell cycle KEGG	34	0.012
ST JNK MAPK pathway	17	0.017
EGF pathway	23	0.023
PDGF pathway	23	0.028
FCER1 pathway	26	0.029
GSK3 pathway	18	0.029
Prostaglandin and leukotriene metabolism	19	0.032
IL6 pathway	17	0.032
HSA02010 ABC transporters general	21	0.033

(b)

Name of biological process gene sets	Number of genes in the gene set	Nominal 𝑃 value
HSA00190 oxidative phosphorylation	37	0.000
Glutamate metabolism	15	0.000
HSA00252 alanine and aspartate metabolism	17	0.010
HSA00710 carbon fixation	15	0.019
HSA00251 glutamate metabolism	17	0.019