Solution Structures of PPARγ2/RXRα Complexes

Figure 3

Molecular envelope of PPARγ/RXRα LBDs complexes and comparison with the crystal structure of PPARγ/RXRα LBDs. (a) Crystal structure of PPARγ/RXRα LBDs in complex with TIF2 coactivator peptide (PDB ID: 1H0A) shown in schematic cartoon representations with PPARγ in yellow, RXRα in cyan, and the coactivator peptides in pink. (b) Crystal structure of PPARγ LBD bound to PGC-1α NR2 motif (PDB ID: 3CS8). (c) Molecular envelopes of the complexes PPARγ/RXRα LBDs (grey surface) together with the crystal structure of the complex. (d) Molecular envelope of the complexes TIF2 RID/PPARγ/RXRα LBDs (grey surface).

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