Review Article
PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy
Table 1
Effects of PPARγ ligands in mouse OVA models of allergic airways disease.
| Strain | Ligand | Inflammation | Remodeling | AHR | Mechanism | References |
| Balb/C | CGZ | IL-4, IL-5, IL-6, IL-13 eosinophils | mucus collagen wall thickness | | GATA-3 | [25, 94] | Balb/C | CGZ | IFNγ, IL-2, IL-4 eosinophils | mucus | N.D. | | [100] | Balb/C | CGZ | eosinophils | ASM thickness | | | [95] | Balb/C | CGZ RGZ | eosinophils | | N.D. | IL-10 | [99] | Balb/C | RGZ PGZ | IL-4, IL-5, IL-13, ECP eosinophils | | | PTEN IL-10 | [27, 47] | Balb/C | GI 262570 | eosinophils | | N.D. | | [92] |
| C57Bl/6 | RGZ PGZ | IL-4, IL-5, IL-13, VEGF, eotaxin, RANTES eosinophils | | | IL-17 via NFB | [93, 97] | C57Bl/6 | RGZ | eosinophils | mucus wall thickness | | | [98] |
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ASM: airway smooth muscle; CGZ: ciglitazone; ECP: eosinophil cationic protein; IL: interleukin; N.D.: not determined; PGZ: pioglitazone; PTEN: phosphatase and tensin homologue deleted on chromosome ten; RANTES: regulated upon activation, normal T-cell expressed, and secreted; RGZ: rosiglitazone; VEGF: vascular endothelial growth factor.
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