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PPAR Research
Volume 2012, Article ID 857142, 9 pages
Review Article

Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation

1Vascular Biology Group, Robarts Research Institute, 100 Perth Drive, London, ON, Canada N6A 5K8
2Departments of Biochemistry and Medicine, The University of Western Ontario, London, ON, Canada N6A 5C1

Received 21 December 2011; Accepted 2 April 2012

Academic Editor: Brian Finck

Copyright © 2012 Erin E. Mulvihill and Murray W. Huff. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Studies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce atherosclerosis. Emerging evidence suggests the metabolic regulators, PPARα and PGC1α, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects. Molecular studies will add significantly to the concept of these flavonoids as viable and promising therapeutic agents to treat the dysregulation of lipid homeostasis, metabolic disease, and its cardiovascular complications.