Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1<i>α</i>-Mediated Fatty Acid Oxidation

<table>Regulation of gene expression by peroxisome proliferator-activated receptors. The nuclear hormone receptor PPAR<i>α</i> induces transcription through formation of a heterodimer with the retinoic X receptor and binding to peroxisome proliferator response elements (most are direct repeats with one intervening nucleotide) in the promoter of genes involved in fatty acid oxidation. PGC1<i>α</i> is an important PPAR<i>α</i> coactivator in tissues that undergo extensive oxidative metabolism and induce mitochondrial expansion.</table>

PPAR Research

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Figure 1

Figure 1: Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1<i>α</i>-Mediated Fatty Acid Oxidation 

Figure 1 | Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation 