Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines

Table 2

(a) Statistical contrasts from multivariate periodic regression analysis, along with a summarization of the decision to be drawn for each comparison, (b) interpretation rules: conclusions to be drawn from the joint hypotheses testing “identical biorhythms” (H₀₁) and “opposing biorhythms” (H₀₂).

(a)

BxPC3 statistical contrasts
Hypotheses	𝐹-value	𝑃-value
H01: Biorhythms of PPARG and DNMT1 are identical	0.57	0.695
H02: Biorhythms of PPARG and DNMT1 are opposing	2.11	0.189
H01: Biorhythms of PPARG and DNMT3B are identical	4.16	0.039
H02: Biorhythms of PPARG and DNMT3B are opposing	0.46	0.764
H01: Biorhythms of DNMT1 and DNMT3B are identical	11.67	0.001
H02: Biorhythms of DNMT1 and DNMT3B are opposing	1.61	0.246
Decisions derived from statistical contrasts
(1) Biorhythms of PPARG and DNMT1 have flat shapes, although statistical tests slightly suggest that they could be identical; (i.e., no sufficient statistical power). (2) Biorhythms of PPARG and DNMT3B are opposing. (3) Biorhythms of DNMT1; and DNMT3B are opposing
CFPAC statistical contrasts
Hypotheses	𝐹-value	𝑃-value
H01: Biorhythms of PPARG and DNMT1 are identical	7.82	0.003
H02: Biorhythms of PPARG and DNMT1 are opposing	6.70	0.021
H01: Biorhythms of PPARG and DNMT3B are identical	43.78	<0.001
H02: Biorhythms of PPARG and DNMT3B are opposing	22.68	<0.001
H01: Biorhythms of DNMT1 and DNMT3B are identical	28.98	<0.001
H02: Biorhythms of DNMT1 and DNMT3B are opposing	38.02	<0.001
Decisions derived from statistical contrasts
(1) Biorhythms of PPARG and DNMT1 are different (neither identical nor opposing). (2) Biorhythms of PPARG and DNMT3B are; different (neither identical nor opposing). (3) Biorhythms of DNMT1 and DNMT3B are different (neither identical nor opposing)
PANC1 statistical contrasts
Hypotheses	𝐹-value	𝑃-value
H01: Biorhythms of PPARG and DNMT1 are identical	52.22	<0.001
H02: Biorhythms of PPARG and DNMT1 are opposing	5.78	0.010
H01: Biorhythms of PPARG and DNMT3B are identical	16.14	0.002
H02: Biorhythms of PPARG and DNMT3B are opposing	3.16	0.070
H01: Biorhythms of DNMT1 and DNMT3B are identical	1.96	0.196
H02: Biorhythms of DNMT1 and DNMT3B are opposing	3.57	0.063
Decisions derived from statistical contrasts
(1) Biorhythms of PPARG and DNMT1 are different (neither identical nor opposing). (2) Biorhythms of PPARG and DNMT3B; are opposing, although statistical tests slightly suggest that they could be different at all. (3) Biorhythms of DNMT1 and DNMT3B have flat shapes, although statistical tests slightly suggest that they could be identical
MIAPACA statistical contrasts
Hypotheses	𝐹-value	𝑃-value
H01: Biorhythms of PPARG and DNMT1 are identical	11.63	<0.001
H02: Biorhythms of PPARG and DNMT1 are opposing	7.23	0.018
H01: Biorhythms of PPARG and DNMT3B are identical	9.89	0.001
H02: Biorhythms of PPARG and DNMT3B are opposing	8.52	0.003
H01: Biorhythms of DNMT1 and DNMT3B are identical	17.71	<0.001
H02: Biorhythms of DNMT1 and DNMT3B are opposing	9.06	0.002
Decisions derived from statistical contrasts
(1) Biorhythms of PPARG and DNMT1 are different (neither identical nor opposing). (2) Biorhythms of PPARG and DNMT3B are; different (neither identical nor opposing). (3) Biorhythms of DNMT1 and DNMT3B are different (neither identical nor opposing)

(b)

			H01“identical biorhythms”
		Rejected	Not-rejected
	Rejected	The biorhythms are different; (neither identical nor opposing)	The biorhythms are identical
H02 “opposing biorhythms”	Not-rejected	The biorhythms are opposing	The biorhythms have flat shape