Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury
Figure 4
The effects of PPARα and PPARα activation on MCP-1 and TF expression after arterial injury determined by real-time PCR. (a) MCP-1 mRNA level was much higher in the PPARα knockout group when compared to WT group; (b) TF mRNA level was much higher in the PPARα knockout group when compared to WT group and WT group treated with Wy14643. PPARα activation further decreased TF expression when compared to untreated WT group but did not reach statistic significance.
