PPAR Research / 2012 / Article / Fig 3

Research Article

PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling

Figure 3

Alteration of intranuclear transcription factor activities. (a) The PPAR response element-binding activities of intranuclear PPARα from glomeruli in each group of anti-Thy1 nephritis rats. (b) The NF-κB response element-binding activities of intranuclear NF-κB in each group. For these assays, the nuclear protein samples were subjected to ELISA in triplicate. The optical density (OD) for each sample was corrected by that of a blank sample and by protein amount in each sample. The data were expressed as changes relative to the value for the control rats (Fib(−) group of rats at day 0). Values are means ± SD. Significant differences from the respective day 0 groups are indicated with number signs (# , ## , ### ), while significant differences between regular-diet and clofibrate-diet groups are indicated with asterisks (* , ** , *** ).

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