PPAR Research / 2012 / Article / Tab 1

Research Article

PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling

Table 1

Systemic change and estimated dose of clofibrate in anti-Thy1 nephritis rats.

ParameterFibrate (−) group0.02% fibrate group0.1% fibrate group
Day 0Day 4Day 7Day 14Day 0Day 4Day 7Day 14Day 0Day 4Day 7Day 14

BW (g)248 ± 26254 ± 33256 ± 38267 ± 54257±16259 ± 48264 ± 35265 ± 47254 ± 21258 ± 39263 ± 30267 ± 40
sBP (mmHg)152 ± 17158 ± 20158 ± 15150±10155 ± 10149 ± 12152 ± 18153 ± 6151 ± 16157 ± 15155 ± 20158 ± 15
HR (beat/min)400 ± 16407 ± 30410 ± 20400 ± 20393 ± 11400 ± 10406 ± 21404±25396 ± 26405 ± 36403 ± 30402±15
FC (g/day)20.1 ± 519 ± 318.5 ± 518.3 ± 518.2 ± 218.7 ± 219.6 ± 218.6 ± 518.9 ± 318.7 ± 119.5 ± 319 ± 6
Clo dose (mg/kg)000014.214.114.814.174.572.474.171.2

BW, body weight; sBP, systolic bood pressure; HR, heart rate; FC, food consumption; Clo, clofibrate.
These parameters were not affected by the induction of anti-Thy1 nephritis. There was no significant difference among groups.

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