PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling
Table 1
Systemic change and estimated dose of clofibrate in anti-Thy1 nephritis rats.
Parameter
Fibrate (−) group
0.02% fibrate group
0.1% fibrate group
Day 0
Day 4
Day 7
Day 14
Day 0
Day 4
Day 7
Day 14
Day 0
Day 4
Day 7
Day 14
BW (g)
248 ± 26
254 ± 33
256 ± 38
267 ± 54
257±16
259 ± 48
264 ± 35
265 ± 47
254 ± 21
258 ± 39
263 ± 30
267 ± 40
sBP (mmHg)
152 ± 17
158 ± 20
158 ± 15
150±10
155 ± 10
149 ± 12
152 ± 18
153 ± 6
151 ± 16
157 ± 15
155 ± 20
158 ± 15
HR (beat/min)
400 ± 16
407 ± 30
410 ± 20
400 ± 20
393 ± 11
400 ± 10
406 ± 21
404±25
396 ± 26
405 ± 36
403 ± 30
402±15
FC (g/day)
20.1 ± 5
19 ± 3
18.5 ± 5
18.3 ± 5
18.2 ± 2
18.7 ± 2
19.6 ± 2
18.6 ± 5
18.9 ± 3
18.7 ± 1
19.5 ± 3
19 ± 6
Clo dose (mg/kg)
0
0
0
0
14.2
14.1
14.8
14.1
74.5
72.4
74.1
71.2
BW, body weight; sBP, systolic bood pressure; HR, heart rate; FC, food consumption; Clo, clofibrate. These parameters were not affected by the induction of anti-Thy1 nephritis. There was no significant difference among groups.
