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PPAR Research
Volume 2013 (2013), Article ID 186312, 7 pages
http://dx.doi.org/10.1155/2013/186312
Review Article

Structural Features and Transcriptional Activity of Chicken PPARs ( , , and )

1Department of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo 160-8582, Japan
2Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160-8582, Japan
3Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan

Received 5 October 2012; Revised 11 December 2012; Accepted 12 December 2012

Academic Editor: Juan J. Loor

Copyright © 2013 Ichiro Takada and Mime Kobayashi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Takada, R. T. Yu, H. E. Xu et al., “Alteration of a single amino acid in peroxisome proliferator-activated receptor-α (PPARα) generates a PPARδ phenotype,” Molecular Endocrinology, vol. 14, no. 5, pp. 733–740, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Hu, J. B. Kim, P. Sarraf, and B. M. Spiegelman, “Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ,” Science, vol. 274, no. 5295, pp. 2100–2103, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. J. H. Choi, A. S. Banks, T. M. Kamenecka et al., “Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation,” Nature, vol. 477, no. 7365, pp. 477–481, 2011. View at Google Scholar
  4. G. Pascual, A. L. Fong, S. Ogawa et al., “A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ,” Nature, vol. 437, no. 7059, pp. 759–763, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Fajas, D. Auboeuf, E. Raspé et al., “The organization, promoter analysis, and expression of the human PPARγ gene,” Journal of Biological Chemistry, vol. 272, no. 30, pp. 18779–18789, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Zhu, C. Qi, J. R. Korenberg et al., “Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 17, pp. 7921–7925, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Sato, K. Fukao, Y. Seki, and Y. Akiba, “Expression of the chicken peroxisome proliferator-activated receptor-γ gene is influenced by aging, nutrition, and agonist administration,” Poultry Science, vol. 83, no. 8, pp. 1342–1347, 2004. View at Google Scholar · View at Scopus
  8. G. Hu, S. Z. Wang, Z. P. Wang, Y. M. Li, and H. Li, “Genetic epistasis analysis of 10 peroxisome proliferator-activated receptor γ-correlated genes in broiler lines divergently selected for abdominal fat content,” Poultry Science, vol. 89, no. 11, pp. 2341–2350, 2010. View at Publisher · View at Google Scholar
  9. N. Ding, Y. Gao, N. Wang, and H. Li, “Functional analysis of the chicken PPARγ gene 5'-flanking region and C/EBPa-mediated gene regulation,” Comparative Biochemistry and Physiology B, vol. 158, no. 4, pp. 297–303, 2011. View at Google Scholar
  10. C. Diot and M. Douaire, “Characterization of a cDNA sequence encoding the peroxisome proliferator activated receptor α in the chicken,” Poultry Science, vol. 78, no. 8, pp. 1198–1202, 1999. View at Google Scholar · View at Scopus
  11. H. Meng, H. Li, J. G. Zhao, and Z. L. Gu, “Differential expression of peroxisome proliferator-activated receptors alpha and gamma gene in various chicken tissues,” Domestic Animal Endocrinology, vol. 28, no. 1, pp. 105–110, 2005. View at Google Scholar
  12. Y. Guan, C. Hao, D. R. Cha et al., “Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption,” Nature Medicine, vol. 11, no. 8, pp. 861–866, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hojo, I. Takada, W. Kimura, K. Fukuda, and S. Yasugi, “Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs,” Gene Expression Patterns, vol. 6, no. 2, pp. 171–179, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Michalik, J. Auwerx, J. P. Berger et al., “International union of pharmacology. LXI. Peroxisome proliferator-activated receptors,” Pharmacological Reviews, vol. 58, no. 4, pp. 726–741, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Shi, Q. Zhang, Y. Wang, P. Yang, Q. Wang, and H. Li, “Chicken adipocyte fatty acid-binding protein knockdown affects expression of peroxisome proliferator-activated receptor γ gene during oleate-induced adipocyte differentiation,” Poultry Science, vol. 90, no. 5, pp. 1037–1044, 2011. View at Google Scholar
  16. T. A. Larkina, A. L. Sazanova, K. A. Fomichev et al., “HMG1A and PPARG are differently expressed in the liver of fat and lean broilers,” Journal of Applied Genetics, vol. 52, no. 2, pp. 225–228, 2011. View at Google Scholar
  17. A. Vidal-Puig, M. Jimenez-Liñan, B. B. Lowell et al., “Regulation of PPAR γ gene expression by nutrition and obesity in rodents,” Journal of Clinical Investigation, vol. 97, no. 11, pp. 2553–2561, 1996. View at Google Scholar · View at Scopus
  18. A. J. Vidal-Puig, R. V. Considine, M. Jimenez-Liñan et al., “Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids,” Journal of Clinical Investigation, vol. 99, no. 10, pp. 2416–2422, 1997. View at Google Scholar · View at Scopus
  19. H. X. Cui, R. R. Liu, G. P. Zhao, M. Q. Zheng, J. L. Chen, and J. Wen, “Identification of differentially expressed genes and pathways for intramuscular fat deposition in pectoralis major tissues of fast-and slow-growing chickens,” BMC Genomics, vol. 13, p. 213, 2012. View at Publisher · View at Google Scholar
  20. S. L. Madsen and E. A. Wong, “Expression of the chicken peptide transporter 1 and the peroxisome proliferator-activated receptor α following feed restriction and subsequent refeeding,” Poultry Science, vol. 90, no. 10, pp. 2295–2300, 2010. View at Publisher · View at Google Scholar
  21. R. Joubert, S. Métayer-Coustard, S. Crochet et al., “Regulation of the expression of the avian uncoupling protein 3 by isoproterenol and fatty acids in chick myoblasts: possible involvement of AMPK and PPARα?” American Journal of Physiology, vol. 301, no. 1, pp. R201–R208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. R. K. Selvaraj, R. Shanmugasundaram, and K. C. Klasing, “Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response,” Comparative Biochemistry and Physiology A, vol. 157, no. 3, pp. 198–203, 2010. View at Google Scholar
  23. K. Umesono and R. M. Evans, “Determinants of target gene specificity for steroid/thyroid hormone receptors,” Cell, vol. 57, no. 7, pp. 1139–1146, 1989. View at Google Scholar · View at Scopus
  24. F. Grun and B. Blumberg, “Identification of novel nuclear hormone receptor ligands by activity-guided purification,” Methods in Enzymology, vol. 364, pp. 3–24, 2003. View at Google Scholar
  25. G. Krey, O. Braissant, F. L'Horset et al., “Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay,” Molecular Endocrinology, vol. 11, no. 6, pp. 779–791, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. X. Wang, C. H. Lee, S. Tiep et al., “Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity,” Cell, vol. 113, no. 2, pp. 159–170, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. B. König, H. Kluge, K. Haase, C. Brandsch, G. I. Stangl, and K. Eder, “Effects of clofibrate treatment in laying hens,” Poultry Science, vol. 86, no. 6, pp. 1187–1195, 2007. View at Google Scholar · View at Scopus
  28. A. Hiukka, M. Maranghi, N. Matikainen, and M. R. Taskinen, “PPARα: an emerging therapeutic target in diabetic microvascular damage,” Nature Reviews Endocrinology, vol. 6, no. 8, pp. 454–463, 2010. View at Publisher · View at Google Scholar · View at Scopus