Research Article
Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 1
Anthropometric and biochemical characteristics of study population.
| | Variables | MS− () | MS+ () | P |
| | Age (years) | 41.0 (29.0–51.7) | 38.0 (29.0–54.0) | 0.695 | | Gender M/F (%) | 137/127 (51.9/48.1) | 128/130 (49.6/50.4) | 0.602 | | Diabetes ( (%)) | 31 (11.7) | 71 (27.9) | <0.001 | Hypertension
( (%)) | 36 (13.6) | 101 (39.7) | <0.001 | | SBP (mmHg) | 120 (115–125) | 140 (130–150) | <0.001 | | DBP (mmHg) | 80 (75–80) | 85 (80–90) | <0.001 | | BMI (kg/m2) | 24.5 (23.7–25.9) | 27.7 (26.4–29.4) | <0.001 | | Men WC (cm) | 93 (89–95) | 98 (96–101) | <0.001 | | Women WC (cm) | 79 (77–86) | 93 (90–98) | <0.001 | | TG (mmol/L) | 1.07 ± 0.44 | 1.91 ± 0.71 | <0.001 | | TC (mmol/L) | 4.51 (4.12–4.99) | 5.15 (4.24–5.78) | <0.001 | | cLDL (mmol/L) | 2.92 (2.52–3.31) | 3.36 (2.76–3.95) | <0.001 | | Men cHDL (mmol/L) | 1.10 (1.02–1.16) | 0.84 (0.74–0.92) | <0.001 | | Women cHDL (mmol/L) | 1.45 (1.34–1.53) | 1.10 (0.89–1.26) | <0.001 | | FPG (mmol/L) | 4.94 ± 0.95 | 6.96 ± 1.78 | <0.001 | | FPI (mIU/L) | 7.12 (5.97–8.61) | 12.73 (9.59–13.22) | <0.001 | | HOMA-β% | 97 (88–109) | 72 (52–94) | <0.001 | | HOMA-S% | 110 (88–130) | 56 (53–78) | <0.001 | | HOMA-IR | 0.9 (0.8–1.1) | 1.8 (1.3–1.9) | <0.001 | | Cr (μmol/L) | 87.5 ± 31 | 111.4 ± 46.4 | <0.001 | | Urea (mmol/L) | 4.46 ± 2.63 | 7.72 ± 4.82 | <0.001 | | UA (μmol/L) | 267.5 (213.5–307.7) | 358 (285–4.28) | <0.001 | | GFR (mL/min) | 92.9 (78.8–107.4) | 85.6 (61.9–106.3) | 0.004 |
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MS−: without metabolic syndrome; MS+: with metabolic syndrome, SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
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