Research Article
Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 2
Leu162Val PPARα and Pro12Ala PPARγ2 genotype and allele distribution.
| | | Total (522) | MS− (264) | MS+ (258) | P | OR (95% CI) |
| | Pro12 Ala PPARγ2 |
| | Allele | | Pro ( (%)) | 882 (84.5)a | 430 (81.4) | 452 (87.6) | 0.006 | 1.610 (1.144–2.265) | | Ala ( (%)) | 162 (15.5) | 98 (18.6) | 64 (12.4) | 0.006 | 0.621 (0.442–0.874) | | Genotype | | Pro/Pro ( (%)) | 369 (70.69) | 174 (65.91) | 195 (75.58) | 0.015 | 1.601 (1.093–2.344) | | Pro/Ala ( (%)) | 144 (27.59) | 82 (31.06) | 62 (24.03) | 0.046 | 0.675 (0.458–0.995) | | Ala/Ala ( (%)) | 9 (1.72) | 8 (3.03) | 1(0.39) | 0.013 | 0.112 (0.014–0.901) |
| | Leu162Val PPARα |
| | Allele | | Leu ( (%)) | 956 (91.6) | 471 (89.2) | 485 (93.9) | 0.005 | 1.893 (1.201–2.985) | | Val ( (%)) | 88 (8.4) | 57 (10.8) | 31 (6.1) | 0.005 | 0.528 (0.335–0.833) | | Genotype | | Leu/Leu ( (%)) | 441 (84.48) | 213 (80.68) | 228 (88.37) | 0.015 | 1.820 (1.117–2.985) | | Leu/Val ( (%)) | 74 (14.17) | 45 (17.05) | 29 (11.24) | 0.046 | 0.602 (0.364–0.995) | | Val/Val ( (%)) | 7 (1.35) | 6 (2.27) | 1 (0.39) | 0.049 | 0.156 (0.019–1.304) |
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Number (% of total); SM−: without metabolic syndrome; SM+: with metabolic syndrome; OR: odds ratio; CI: confidence interval.
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