Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 3
Anthropometric, HOMA index, and biochemical characteristics of subjects with different groups of genotype of the Leu162Val PPARα and Pro12Ala PPARγ2 polymorphisms.
Parameters
Pro12Ala PPARγ2
Leu162Val PPARα
P/P ( = 369)
X/A ( =153)
P
L/L ( = 441)
X/V ( = 81)
P
Age (years)
41 (29–53)
38 (28–49)
0.088
39 (29–53)
38 (29–48)
0.177
SBP (mmHg)
125 (120–140)
125 (120–135)
0.102
125 (120–140)
130 (120–135)
0.854
DBP (mmHg)
80 (80–85)
80 (80–85)
0.127
80 (80–85)
80 (80–85)
0.465
BMI (kg/m2)
26.4 (24.4–28.3)
25.6 (24.1–27.9)
0.108
25.9 (24.3–28.2)
26.6 (24.4–29.1)
0.201
WC (cm)
93.0 (85.0–98.0)
93.0 (81.5–97)
0.404
93.0 (83.0–97.0)
94.0 (86.5–98.5)
0.076
TG (mmol/L)
1.51 ± 0.71
1.43 ± 0.76
0.186
1.50 ± 0.72
1.44 ± 0.72
0.497
TC (mmol/L)
4.73 (4.19–5.49)
4.71 (4.11–5.27)
0.271
4.72 (4.19–5.45)
4.71 (4.12–5.41)
0.526
cLDL (mmol/L)
3.09 (2.61–3.71)
3.00 (2.62–3.67)
0.513
3.07 (2.62–3.73)
3.09 (2.57–3.63)
0.410
cHDL (mmol/L)
1.12 (0.88–1.27)
1.09 (0.90–1.34)
0.368
1.11 (0.88–1.29)
1.12 (0.92–1.33)
0.475
FPG (mmol/L)
6.14 ± 1.77
5.45 ± 1.57
<0.001
6.05 ± 1.79
5.36 ± 1.30
0.001
FPI (mIU/L)
9.83 (7.12–12.88)
7.85 (6.16–11.22)
<0.001
9.23 (6.92–12.83)
8.91 (6.65–11.95)
0.139
HOMA-β%
86 (64–100)
95 (82–105)
<0.001
88 (67–99)
95 (80–119)
<0.001
HOMA-S%
77 (54–109)
102 (68–126)
<0.001
80 (55–112)
85 (62–118)
0.043
HOMA-IR
1.3 (0.9–1.8)
1.0 (0.8–1.5)
<0.001
1.2 (0.9–1.8)
1.2 (0.9–1.6)
0.067
Cr (μmol/L)
102.1 ± 45.8
92.5 ± 25.2
0.016
99.6 ± 41.6
97.9 ± 38.2
0.749
Urea (mmol/L)
6.45 ± 4.33
5.17 ± 2.34
0.001
6.29 ± 4.13
4.89 ± 1.83
0.003
UA (μmol/L)
307 (248–385)
292 (234–350)
0.036
306 (247–382)
292 (233–341)
0.042
GFR (mL/min)
89.5 (72.7–105.1)
93.8 (71.6–111.3)
0.004
89.0 (71.5–104.9)
102.6 (76.1–113.5)
0.002
P: Pro; A: Ala; L: Leu; V: Val; X/A: Pro/Ala and Ala/Ala; X/V: Leu/Val and Val/Val. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
