Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 4
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Pro12Ala PPARγ2 genotypes in two subdivided groups according to metabolic syndrome.
Parameters
SM−
SM+
Pro12Ala PPARγ2
Pro12Ala PPARγ2
P/P ( = 174)
X/A ( = 90)
P
P/P ( = 195)
X/A ( = 63)
P
Age (years)
42 (29–53)
38 (28–49)
0.455
39 (29–56)
37 (28–49)
0.103
SBP (mmHg)
120 (115–125)
120 (115–125)
0.708
140 (130–150)
140 (130–145)
0.675
DBP (mmHg)
80 (75–80)
80 (70–80)
0.277
85 (80–90)
85 (80–90)
0.965
BMI (kg/m2)
24.5 (23.8–25.9)
24.4 (23.6–25.7)
0.228
27.7 (26.3–29.4)
27.6 (26.5–29.3)
0.940
WC (cm)
87 (79–93)
90 (79–93)
0.758
96 (92–99)
96 (93–99)
0.997
TG (mmol/L)
1.07 ± 0.43
1.07 ± 0.43
0.942
1.91 ± 0.67
1.92 ± 0.84
0.964
TC (mmol/L)
4.51 (4.15–4.85)
4.62 (4.02–5.17)
0.633
5.18 (4.27–5.78)
4.81 (4.19–5.59)
0.190
cLDL (mmol/L)
2.90 (2.54–3.29)
2.98 (2.40–3.53)
0.729
3.48 (2.76–4.10)
3.24 (2.85–3.85)
0.499
cHDL (mmol/L)
1.18 (1.11–1.43)
1.19 (1.04–1.46)
0.868
0.91 (0.79–1.17)
0.92 (0.77–1.14)
0.925
FPG (mmol/L)
4.94 ± 1.09
4.95 ± 0.87
0.946
7.21 ± 1.67
6.16 ± 1.86
<0.001
FPI (mIU/L)
7.13 (6.14–8.65)
6.93 (5.61–8.58)
0.277
12.83 (10.76–13.29)
10.58 (7.92–12.98)
<0.001
HOMA-β%
96 (87–111)
97 (88–106)
0.698
68 (52–88)
86 (71–101)
<0.001
HOMA-S%
108 (87–128)
113 (89–140)
0.270
56 (53–66)
70 (55–103)
<0.001
HOMA-IR
0.9 (0.8–1.2)
0.9 (0.7–1.1)
0.282
1.8 (1.5–1.9)
1.4 (1.0–1.8)
<0.001
Cr (μmol/L)
87.29 ± 36.16
87.87 ± 25.2
0.579
115.35 ± 49.51
99.30 ± 32.42
0.017
Urea (mmol/L)
4.52 ± 3.05
4.35 ± 17.24
0.619
6.33 ± 2.78
8.16 ± 4.58
0.003
UA (μmol/L)
268 (210–313)
266 (215–306)
0.996
358 (285–437)
348 (278–396)
0.062
GFR (mL/min)
93.4 (82.3–106.4)
91.5 (70.5–109.1)
0.192
84.0 (58.8–104.5)
98.8 (78.8–113.8)
0.001
P: Pro; A: Ala; X/A: Pro/Ala and Ala/Ala. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
