Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 5
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Leu162Val PPARα genotypes in two subdivided groups according to metabolic syndrome.
Parameters
SM−
SM+
Leu162Val PPARα
Leu162Val PPARα
L/L ( = 213 )
X/V ( = 51)
P
L/L ( = 228 )
X/V ( = 30)
P
Age (years)
42 (29–52)
38 (32–49)
0.566
39 (29–56)
36 (29–45)
0.898
SBP (mmHg)
120 (115–120)
120 (120–130)
0.073
140 (130–150)
135 (130–150)
0.300
DBP (mmHg)
80 (75–80)
80 (75–80)
0.260
85 (80–90)
85 (80–90)
0.090
BMI (kg/m2)
24.5 (23.7–25.8)
25.0 (23.9–28.1)
0.172
27.7 (26.4–29.4)
27.6 (26.5–29.4)
0.400
WC (cm)
86 (79–93)
93 (84–97)
0.658
96 (92–99)
96 (93–100)
0.615
TG (mmol/L)
1.06 ± 0.44
1.09 ± 0.42
0.691
1.90 ± 0.70
2.02 ± 0.77
0.382
TC (mmol/L)
4.51 (4.14–4.93)
4.53 (3.90–5.06)
0.659
5.15 (4.22–5.78)
5.12 (4.23–5.78)
0.330
cLDL (mmol/L)
2.92 (2.52–3.31)
2.97 (2.31–3.40)
0.717
3.42 (2.76–4.03)
3.30 (2.83–3.85)
0.351
cHDL (mmol/L)
1.19 (1.10–1.46)
1.16 (1.04–1.39)
0.777
0.90 (0.79–1.14)
0.95 (0.82–1.28)
0.935
FPG (mmol/L)
4.94 ± 0.96
4.96 ± 0.88
0.846
7.08 ± 1.76
6.02 ± 1.60
0.002
FPI (mIU/L)
7.06 (5.86–8.25)
7.48 (6.17–10.04)
0.626
12.77 (10.09–13.25)
11.26 (7.85–13.03)
0.879
HOMA-β%
97 (88–105)
100 (86–121)
0.283
69 (52–93)
85 (66–106)
0.219
HOMA-S%
111 (95–134)
103 (75–126)
0.602
56 (53–73)
64 (56–99)
0.564
HOMA-IR
0.9 (0.8–1.1)
1.0 (0.8–1.3)
0.761
1.8 (1.4–1.9)
1.6 (1.0–1.8)
0.457
Cr (μmol/L)
86.3 ± 32.6
92.3 ± 22.5
0.216
111.9 ± 45.2
107.6 ± 54.7
0.631
Urea (mmol/L)
4.55 ± 2.87
4.12 ± 1.17
0.303
7.92 ± 4.46
6.02 ± 2.01
0.039
UA (μmol/L)
268 (206–313)
250 (223–302)
0.752
358 (285–433)
348 (288–398)
0.847
GFR (mL/min)
91.7 (79.4–105.8)
99.1 (71.6–109.4)
0.302
84.5 (60.4–104.7)
108.8 (82.1–124.5)
0.679
L, Leu; V, Val; X/V: Leu/Val and Val/Val. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
