Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 6
Comparison of anthropometric, HOMA index, and biochemical characteristics of subjects between different groups of Pro12Ala PPARγ2 genotypes in two subdivided groups according to age.
Parameters
Age < 60 years
Age ≥ 60 years
Pro12Ala PPARγ2
Pro12Ala PPARγ2
P/P ( = 289)
X/A ( = 125)
P
P/P ( = 80)
X/A ( = 28)
P
Age (years)
36 (29–46)
35 (28–41)
0.094
62 (59–66)
64 (59–69)
0.287
SBP (mmHg)
125 (120–140)
125 (120–130)
0.110
130 (120–140)
130 (120–140)
0.845
DBP (mmHg)
80 (80–85)
80 (80–80)
0.065
80 (80–85)
80 (75–90)
0.709
BMI (kg/m2)
26.0 (24.3–28.3)
25.4 (24.2–27.9)
0.276
26.9 (24.7–27.8)
25.9 (23.7–28.1)
0.237
WC (cm)
93.0 (84.0–98.0)
93.0 (82.5–97)
0.568
93.0 (86.0–98.0)
91.0 (79.0–97.5)
0.448
TG (mmol/L)
1.48 ± 0.71
1.44 ± 0.78
0.577
1.63 ± 0.70
1.34 ± 0.67
0.058
TC (mmol/L)
4.68 (4.11–5.45)
4.68 (4.10–5.25)
0.665
5.03 (4.46–5.68)
4.74 (4.10–5.57)
0.185
cLDL (mmol/L)
3.09 (2.61–3.71)
3.00 (2.54–3.66)
0.918
3.31 (2.92–3.84)
3.09 (2.82–3.84)
0.308
cHDL (mmol/L)
1.13 (0.88–1.28)
1.13 (0.91–1.34)
0.425
1.03 (0.88–1.24)
1.05 (0.87–1.41)
0.596
FPG (mmol/L)
6.08 ± 1.75
5.42 ± 1.49
<0.001
6.36 ± 1.84
5.58 ± 1.91
0.057
FPI (mIU/L)
9.74 (7.12–12.88)
7.92 (6.18–11.09)
<0.001
10.47 (7.30–12.89)
7.52 (6.01–11.49)
0.049
HOMA-β%
88 (66–101)
96 (82–106)
0.002
81 (55–99)
91 (82–103)
0.056
HOMA-S%
79 (55–110)
102 (68–126)
<0.001
73 (53–104)
103 (67–131)
0.030
HOMA-IR
1.3 (0.9–1.8)
1.0 (0.8–1.5)
<0.001
1.4 (1.0–1.9)
1.0 (0.8–1.5)
0.038
Cr (μmol/L)
100.0 ± 45.4
89.3 ± 19.7
0.012
109.6± 47.1
107.0 ± 39.0
0.377
Urea (mmol/L)
6.15 ± 4.05
5.05 ± 2.19
0.005
7.54 ± 5.08
5.70 ± 2.90
0.073
UA (μmol/L)
302 (247–387)
294 (241–353)
0.143
319 (248–383)
279 (211–347)
0.083
GFR (mL/min)
93.5 (83.3–109.4)
101.9 (85.2–112.9)
0.054
66.4 (48.9–77.6)
60.2 (52.7–71.6)
0.002
P: Pro; A: Ala; L: Leu; X/A: Pro/Ala and Ala/Ala. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
