Interaction Effects of the Leu162Val PPARα and Pro12Ala PPARγ2 Gene Variants with Renal Function in Metabolic Syndrome Population
Table 8
Anthropometric and biochemical characteristics of subjects within different groups according to the simultaneous existence of different genotypes of the Leu162Val PPARα and Pro12Ala PPARγ2 polymorphisms.
L/L P/P ()
L/L X/A ()
P/P X/V ()
X/A X/V ()
P
Age (years)
41 (29–54)
38 (28–49)
38 (29–47)
37 (28–49)
0.298
SBP (mmHg)
125 (120–140)
125 (120–140)
125 (120–140)
130 (120–135)
0.284
DBP (mmHg)
80 (80–85)
80 (80–85)
80 (80–90)
80 (75–80)
0.216
BMI (kg/m2)
26.4 (24.4–28.2)
24.9 (23.9–27.3)
26.0 (24.5–29.1
27.1 (24.2–29.1)
0.053
WC (cm)
93 (85–98)
93 (79–96)
93 (85–98)
95 (88–98)
0.052
TG (mmol/L)
1.53 ± 0.71
1.40 ± 0.75
1.38 ± 0.66
1.49 ± 0.79
0.289
TC (mmol/L)
4.73 (4.19–5.49)
4.71 (4.12–5.25)
4.73 (4.13–5.43)
4.71 (4.03–5.35)
0.645
cLDL (mmol/L)
3.13 (2.61–3.74)
3.00 (2.62–3.65)
3.06 (2.53–3.43)
3.20 (2.53–3.72)
0.578
cHDL (mmol/L)
1.09 (0.88–1.26)
1.13 (0.92–1.39)
1.17 (1.03–1.38)
1.05 (0.84–1.32)
0.028
FPG (mmol/L)
6.22 ± 1.80
5.55 ± 1.67
5.54 ± 1.32
5.18 ± 1.27
<0.001
FPI (mIU/L)
10.36 (7.12–12.89)
7.49 (6.02–10.93)
8.92 (6.95–12.44)
8.91 (6.16–11.26)
<0.001
HOMA-β%
84 (59–99)
94 (80–101)
89 (74–115)
99 (88–120)
<0.001
HOMA-S%
73 (54–108)
82 (58–117)
85 (59–115)
87 (67–128)
<0.001
HOMA-IR
1.4 (0.9–1.8)
1.2 (0.8–1.7)
1.2 (0.9–1.7)
1.1 (0.8–1.5)
<0.001
Cr (μmol/L)
102.7 ± 46.2
90.4 ± 21.2
97.5 ± 42.9
98.4 ± 33.5
0.056
Urea (mmol/L)
6.61 ± 4.51
5.36 ± 4.54
5.15 ± 2.04
4.65 ± 1.59
<0.001
UA (μmol/L)
313.0 (248.0–399.0)
301.5 (237.5–360.2)
304.0 (236.5–346.0)
266.0 (225.0–331.0)
0.017
GFR (mL/min)
87.9 (71.7–104.5)
91.5 (71.5–109.4)
101.5 (84.0–112.8)
102.6 (72.6–118.2)
0.011
P: Pro; A: Ala; L: Leu; V: Val; X/A: Pro/Ala and Ala/Ala; X/V: Leu/Val and Val/Val. SBP: systolic blood pressure, DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; TG: triglycerides; TC: total cholesterol; cHDL: high density lipoprotein cholesterol; cLDL: low density lipoprotein cholesterol; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HOMA-β%: % β-cell function; HOMA-S%: % cell insulin sensitivity; HOMA-IR: insulin resistance; Cr: creatinine; UA: uric acid; GFR: glomerular filtration rate.
