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PPAR Research
Volume 2013 (2013), Article ID 401274, 8 pages
Research Article

Does Pro12Ala Polymorphism Enhance the Physiological Role of PPAR 2?

1Unit of Molecular Mechanisms of Disease (CISA) and Chemical and Biomolecular Sciences, School of Allied Health Sciences, Polytechnic Institute of Porto (ESTSP-IPP), Portugal
2Center of Pharmacology and Chemical Biopathology (U38-FCT), Medical Faculty, University of Porto, Portugal
3Center for Research in Health Technologies and Information Systems (CINTESIS), Medical Faculty, University of Porto, Portugal
4Biomathematics, Biostatistics and Bioinformatics, ESTSP-IPP, Porto, Portugal

Received 5 April 2013; Accepted 29 June 2013

Academic Editor: Jörg Mey

Copyright © 2013 A. C. Pereira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity and type 2 diabetes mellitus (T2D) are two major public health problems that have motivated the scientific community to investigate the high contribution of genetic factors to these disorders. The peroxisome proliferator activated by gamma 2 (PPAR 2) plays an important role in the lipid metabolism. Since PPAR 2 is expressed mainly in adipose tissue, a moderate reduction of its activity influences the sensitivity to insulin, diabetes, and other metabolic parameters. The present study aims to contribute to the elucidation of the impact of the Pro12Ala polymorphism associated with T2D and obesity through a meta-analysis study of the literature that included approximately 11500 individuals, from which 3870 were obese and 7625 were diabetic. Statistical evidence supports protective effect in T2D of polymorphism Pro12Ala of PPAR 2 (OR = 0.702 with 95% CI: 0.622; 0.791, ). Conversely the same polymorphism Pro12Ala of PPAR 2 seems to favor obesity since 1.196 more chance than nonobese was found (OR = 1.196 with 95% CI: 1.009; 1.417, ). Our results suggest that Pro12Ala polymorphism enhances both adipogenic and antidiabetogenic physiological role of PPAR . Does Pro12Ala polymorphism represent an evolutionary step towards the stabilization of the molecular function of PPAR transcription factor signaling pathway?