Review Article
Peroxisome Proliferator-Activated Receptor Genetic Polymorphisms and Nonalcoholic Fatty Liver Disease: Any Role in Disease Susceptibility?
Table 2
Characteristics of the studies on the association between the Pro12Ala variant of PPAR
and nonalcoholic fatty liver disease.
| First author, year | Ref. | Ethnicity, country | Study design, sample size () | Patients characteristics | Liver biopsy () | Female sex, (%) |
| Dongiovanni, 2010 | [25] | Caucasian, Italy | Case-control
| Histologically proven NAFLD | | 41 (20) | Gawrieh, 2011 | [51] | Caucasian, USA | Case-control
| Histologically proven NAFLD | | 145 (68) | Gupta, 2011 | [52] | Asian, India | Case-control
| Diagnosis based on ultrasound | | 32 (33) | Rey, 2010 | [53] | Caucasian, Germany | Case-control
| Histologically proven NAFLD | | Not specified | Yang, 2012 | [54] | Asian, China | Case-control
| Diagnosis based on ultrasound | ā | 280 (64) |
|
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Ref: reference number; : number; NAFLD: nonalcoholic fatty liver disease.
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