Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor δ Expression in Rats
Figure 1
PPARδ expression and TnI phosphorylation in hearts from DOX-treated rats, GW0742-added DOX-treated rats, or Wistar rats. Changes in cardiac PPARδ protein expression (a) and the levels of cardiac TnI phosphorylation (b) were examined in age-matched Wistar rats (control rats), DOX-treated rats, and GW0742-added DOX-treated rats. All values are expressed as mean ± SEM ( per group). and as compared with Wistar rats.