Doxorubicin-Induced Cardiac Toxicity Is Mediated by Lowering of Peroxisome Proliferator-Activated Receptor δ Expression in Rats

Figure 3

Effects of doxorubicin on PPARδ expression and cardiac troponin I phosphorylation in neonatal rat cardiomyocytes. Cardiomyocytes from neonatal rats were cultured with 10⁻⁹~10⁻⁶ mol/L doxorubicin for 24 h. These cells were harvested to determine the expression of PPARδ (a) and the level of troponin I phosphorylation (b) using Western blotting analysis. All values are presented as mean ± SEM (𝑛=6 per group). ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 as compared with control cells.

(a)

(b)