Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP
LSN862 (LSN) affected mRNA expression at 24 hrs, 72 hrs, and 21 days post-MPTP. Quantitative PCR analysis of nigral (a) gp91 phox, (b) SOD2, (c) MAC-1, and (d) GFAP and striatal (e) PPAR-γ, (f) PGC1α mRNA levels. The groups were vehicle + PBS (24 hrs: ; 72 hrs: ; 21 days: ); vehicle + MPTP (24 hrs: ; 72 hrs: ; 21 days: ); 30 mg/kg LSN + PBS (24 hrs: ; 72 hrs: ; 21 days ; 30 mg/kg LSN + MPTP (24 hrs: ; 72 hrs ; 21 days ). Data is expressed as fold change from vehicle + PBS controls relative to -actin (mean ± SEM). Two-way ANOVA with repeated measures, # (vehicle + MPTP versus vehicle + PBS), * (vehicle + MPTP versus 30 mg/kg LSN + MPTP), and ** (vehicle + PBS versus 30 mg/kg LSN + PBS).